Issue 59, 2023

Preparation of new chiral diene ligands and their use in the rhodium catalyzed asymmetric annulation of 2-formylarylboronic acid with dialkylalkynes

Abstract

Herein, we report the rhodium-catalyzed domino arylation/cyclization reaction of unactivated internal alkynes to afford the optically active indenols in excellent yields (up to 92%) and extremely high enantioselectivities (up to 99% ee) in the presence of new amide substituted chiral diene ligands. Notably, a total of 21 new chiral diene ligands are synthesized, which are potential choices for other asymmetric reactions.

Graphical abstract: Preparation of new chiral diene ligands and their use in the rhodium catalyzed asymmetric annulation of 2-formylarylboronic acid with dialkylalkynes

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2023
Accepted
28 Jun 2023
First published
28 Jun 2023

Chem. Commun., 2023,59, 9102-9105

Preparation of new chiral diene ligands and their use in the rhodium catalyzed asymmetric annulation of 2-formylarylboronic acid with dialkylalkynes

Y. Sun, Y. Li, X. Wang, X. Cao, H. Deng, X. Bu, M. Ma and F. Xue, Chem. Commun., 2023, 59, 9102 DOI: 10.1039/D3CC02330C

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