Issue 59, 2023
From the journal:

Chemical Communications

Gold catalyzed hydrofluorination of propargyl alcohols promoted by fluorine-hydrogen bonding†

Hui Yang,a   Shaowen Wang,a   Jie Wang,a   Xiangsheng Xu ORCID logo *a  and  Xiaoqing Li ORCID logo *a  

* Corresponding authors

a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: future@zjut.edu.cn, xqli@zjut.edu.cn

Abstract

The hydroxyl group was discovered to promote gold catalyzed hydrofluorination of alkynes via hydrogen bonding interaction. Based on this strategy, propargyl alcohols could be hydrofluorinated smoothly using Et3N·3HF under acidic additive-free conditions, which provided a straightforward alternative protocol for the synthesis of 3-fluoroallyl alcohols.

Graphical abstract: Gold catalyzed hydrofluorination of propargyl alcohols promoted by fluorine-hydrogen bonding

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Article information

DOI
https://doi.org/10.1039/D3CC02275G
Article type
Communication
Submitted
10 May 2023
Accepted
26 Jun 2023
First published
26 Jun 2023

Chem. Commun., 2023,59, 9078-9081

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Gold catalyzed hydrofluorination of propargyl alcohols promoted by fluorine-hydrogen bonding

H. Yang, S. Wang, J. Wang, X. Xu and X. Li, Chem. Commun., 2023, 59, 9078 DOI: 10.1039/D3CC02275G

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