Issue 46, 2023

Hydrophobic cyclic dipeptides as M+/Cl carriers

Abstract

Transmembrane ion-pair co-transport using synthetic transporters is non-trivial. Herein, cyclic dipeptide ion-carriers with dangling ester motifs to bind cations and amide-NH to bind anions are reported. The pendant lipophilic norbornene units aid in membrane insertion to achieve MCl co-transport with this simple design.

Graphical abstract: Hydrophobic cyclic dipeptides as M+/Cl− carriers

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2023
Accepted
16 May 2023
First published
16 May 2023

Chem. Commun., 2023,59, 7068-7071

Hydrophobic cyclic dipeptides as M+/Cl carriers

U. A. Hale and N. Madhavan, Chem. Commun., 2023, 59, 7068 DOI: 10.1039/D3CC02132G

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