A photoactivated H2S donor based on a coumarin structure with real-time monitoring capability

Nianwei Wang; Yuxi Fang; Xuan Wang; Jiao Bai; Huiming Hua; Dahong Li

doi:10.1039/D3CC02053C

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A photoactivated H₂S donor based on a coumarin structure with real-time monitoring capability†

Nianwei Wang,^a Yuxi Fang,^a Xuan Wang,^a Jiao Bai,*^a Huiming Hua

^a and Dahong Li

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China
E-mail: lidahong0203@163.com

Abstract

Attaining controlled, biocompatible H₂S donors poses significant challenges. We developed Bhc-TCN-Ph, a photoactivated H₂S donor derived from 6-bromo-7-hydroxycoumarinmethyl thiocarbonate. Upon 365 nm light exposure, COS is released, generating H₂S and coumarin fluorescence for visualization. This process produces no electrophilic by-products. In vitro evaluations reveal good cytochemical and cytocompatibility characteristics.

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Article information

DOI: https://doi.org/10.1039/D3CC02053C
Article type: Communication
Submitted: 27 Apr 2023
Accepted: 13 Jun 2023
First published: 13 Jun 2023

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Chem. Commun., 2023,59, 8949-8952

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A photoactivated H₂S donor based on a coumarin structure with real-time monitoring capability

N. Wang, Y. Fang, X. Wang, J. Bai, H. Hua and D. Li, Chem. Commun., 2023, 59, 8949 DOI: 10.1039/D3CC02053C

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Chemical Communications