Issue 58, 2023

Rapid post-synthetic modification of porous coordination cages with copper-catalyzed click chemistry

Abstract

Novel cobalt calixarene-capped and zirconium-based porous coordination cages were prepared with alkyne and azide functionality to leverage post-synthetic modification by click chemistry. While the calixarene-capped cages showed impressive stability when exposed to the most straightforward copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reaction conditions with copper(II) sulfate and sodium ascorbate as the reducing agent, milder reaction conditions were necessary to perform analogous CuAAC reactions on zirconium-based cages. Reaction kinetics were monitored by IR spectroscopy, confirming rapid reaction times (<3 hours).

Graphical abstract: Rapid post-synthetic modification of porous coordination cages with copper-catalyzed click chemistry

Supplementary files

Article information

Article type
Communication
Submitted
25 Apr 2023
Accepted
26 May 2023
First published
26 May 2023

Chem. Commun., 2023,59, 8977-8980

Author version available

Rapid post-synthetic modification of porous coordination cages with copper-catalyzed click chemistry

M. R. Dworzak, C. M. Montone, N. I. Halaszynski, G. P. A. Yap, C. J. Kloxin and E. D. Bloch, Chem. Commun., 2023, 59, 8977 DOI: 10.1039/D3CC02015K

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