A high-performance electrochemical biosensor using an engineered urate oxidase†
Zheng
Wei, 
a
Tanja
Knaus,
a
Yuxin
Liu,
a
Andrea F. G.
Gargano,
a
Gadi
Rothenberg,
a
Ning
Yan
a
and
Francesco G.
Mutti
*a
a
Tanja
Knaus,
a
Yuxin
Liu,
a
Andrea F. G.
Gargano,
a
Gadi
Rothenberg,
a
Ning
Yan
a
and
Francesco G.
Mutti
*a
Abstract
We constructed a high-performance biosensor for detecting uric acid by immobilizing an engineered urate oxidase on gold nanoparticles deposited on a carbon-glass electrode. This biosensor showed a low limit-of-detection (9.16 nM), a high sensitivity (14 μA/μM), a wide range of linearity (50 nM–1 mM), and more than 28 days lifetime.
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