The presence of the target causes the structural switch of a metastable hairpin template probe (MH) for triggering a self-primed artificial biochemical circuit to produce numerous DNAzyme replicates, which in turn results in substantial signal amplification for highly sensitive colorimetric determination of nucleic acids.
X. Meng, H. Gu, X. Yin, H. Yi and Y. Chen, Chem. Commun., 2023, 59, 7939 DOI: 10.1039/D3CC01765F
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