Issue 53, 2023
From the journal:

Chemical Communications

A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression†

Kaixin Lyu ORCID logo a  and  Chun Kit Kwok ORCID logo *ab  

* Corresponding authors

a Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China

b Shenzhen Research Institute of City University of Hong Kong, Shenzhen, China
E-mail: ckkwok42@cityu.edu.hk
Web: https://twitter.com/kitkwok6

Abstract

We identify and characterize an RNA G-quadruplex (rG4) structure motif in the human microRNA 638 (hsa-miR-638). We investigate the formation and role of this rG4 in vitro and in cells, and reveal that it inhibits the miR-638 and MEF2C messenger RNA interaction and controls gene expression at the translational level.

Graphical abstract: A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression

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Article information

DOI
https://doi.org/10.1039/D3CC01549A
Article type
Communication
Submitted
31 Mar 2023
Accepted
02 Jun 2023
First published
13 Jun 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 8230-8233

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A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression

K. Lyu and C. K. Kwok, Chem. Commun., 2023, 59, 8230 DOI: 10.1039/D3CC01549A

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