Issue 38, 2023
From the journal:

Chemical Communications

Intermolecular proton transfer from flavonol to human serum albumin triggers a red-shifted ratiometric fluorescence response†

Zhongyong Xu,a   Mingyuan Zhang,a   Zihao Chen,a   Yutian Zhao,a   Lei Wang, ORCID logo a   Xiaoqiang Chen,a   Bin Liu ORCID logo *a  and  Xiaojun Peng ORCID logo ab  

* Corresponding authors

a College of Material Science and Engineering, State Key Laboratory of Fine Chemicals, Shenzhen University, Shenzhen 518060, P. R. China
E-mail: bliu@szu.edu.cn

b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. China

Abstract

Intermolecular proton transfer from a flavonol-based probe to the arginine (Arg222) in drug site 1 of human serum albumin triggers an unusual red-shifted ratiometric fluorescence response, which can be applied in the point-to-care diagnosis of hypoalbuminemia.

Graphical abstract: Intermolecular proton transfer from flavonol to human serum albumin triggers a red-shifted ratiometric fluorescence response

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Article information

DOI
https://doi.org/10.1039/D3CC01546G
Article type
Communication
Submitted
30 Mar 2023
Accepted
19 Apr 2023
First published
19 Apr 2023

Chem. Commun., 2023,59, 5775-5778

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Intermolecular proton transfer from flavonol to human serum albumin triggers a red-shifted ratiometric fluorescence response

Z. Xu, M. Zhang, Z. Chen, Y. Zhao, L. Wang, X. Chen, B. Liu and X. Peng, Chem. Commun., 2023, 59, 5775 DOI: 10.1039/D3CC01546G

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