Issue 51, 2023

Ring expansion and fused cyclization catalysis to construct indoloquinazolinones with functionalization

Abstract

In this study, a straightforward, moisture insensitive, and regioselective FeIII–CuII/p-TSA–CuI catalyzed reaction is achieved from readily available isatin and 2-alkynylaniline to furnish diverse 12-benzoyl/benzyl/alkyl indolo[1,2-c]quinazolin-6(5H)-ones. This catalytic method includes C–C cleavage, multi bond forming ring expansion, fused-ring construction, broad substrate scope, gram-scale producibility, and high atom economy.

Graphical abstract: Ring expansion and fused cyclization catalysis to construct indoloquinazolinones with functionalization

Supplementary files

Article information

Article type
Communication
Submitted
23 Mar 2023
Accepted
15 May 2023
First published
15 May 2023

Chem. Commun., 2023,59, 7978-7981

Ring expansion and fused cyclization catalysis to construct indoloquinazolinones with functionalization

R. Baidya, P. Das, P. Pratihar and D. K. Maiti, Chem. Commun., 2023, 59, 7978 DOI: 10.1039/D3CC01429K

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