Issue 42, 2023

Catalytic C–H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ

Abstract

Iridium-catalysed regioselective C–H alkynylation of unprotected primary benzylamines and aliphatic aldehydes has been achieved using in situ-installed aldimine directing groups. This protocol provides a straightforward route for the synthesis of the alkynylated primary benzylamine and aliphatic aldehyde derivatives, featuring good substrate compatibility and high regioselectivity.

Graphical abstract: Catalytic C–H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ

Supplementary files

Article information

Article type
Communication
Submitted
22 Mar 2023
Accepted
26 Apr 2023
First published
27 Apr 2023

Chem. Commun., 2023,59, 6355-6358

Catalytic C–H alkynylation of benzylamines and aldehydes with aldimine-directing groups generated in situ

J. Zhou, T. Jiao, Q. Fu, J. Wang, J. Lu, L. Yang, J. Wei, S. Wei, X. Cong and N. Hao, Chem. Commun., 2023, 59, 6355 DOI: 10.1039/D3CC01414B

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