Issue 40, 2023

Ultrahigh magnetic resonance contrast switching with water gated polymer–silica nanoparticles

Abstract

Very high T1 magnetic resonance imaging (MRI) switches can be obtained with pH-responsive polymer-coated paramagnetic mesoporous silica nanoparticles (MSNs), as the local environment traverses the pKa of the polymer coat (Δr1 ∼ 50 mM−1 s−1 at 1.5 T and Δr1 ∼ 22 mM−1 s−1 at 3 T). We assign these characteristics to a strong peripheral hydration capping at the mesopores, impacting channel-confined water mobility such that outer sphere contributions to contrast are greatly enhanced.

Graphical abstract: Ultrahigh magnetic resonance contrast switching with water gated polymer–silica nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
10 Mar 2023
Accepted
17 Apr 2023
First published
20 Apr 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 6008-6011

Ultrahigh magnetic resonance contrast switching with water gated polymer–silica nanoparticles

D. Yuan, C. M. Ellis, F. E. Mózes and J. J. Davis, Chem. Commun., 2023, 59, 6008 DOI: 10.1039/D3CC01205K

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