Single-atom-anchored microsweepers for H. pylori inhibition through dynamically navigated reciprocating locomotion

Xinqi Cai; Zhiyang Li; Wen-jing Zhou; Hui Deng; Xiaoxu Cao; Jieqiong Xu; Zhiwei Yin; Shen Wang; Xin Xia; Chao Ma; Long Chen; Ding Ding; Weihong Tan; Zhuo Chen

doi:10.1039/D3CC00933E

Single-atom-anchored microsweepers for H. pylori inhibition through dynamically navigated reciprocating locomotion†

Xinqi Cai,^a Zhiyang Li,^a Wen-jing Zhou,^a Hui Deng,^a Xiaoxu Cao,^a Jieqiong Xu,^a Zhiwei Yin,^a Shen Wang,^a Xin Xia,^a Chao Ma,^b Long Chen,^c Ding Ding,*^d Weihong Tan

^ade and Zhuo Chen

*^a

Author affiliations

* Corresponding authors

^a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, China

^b College of Materials Science and Engineering, Hunan University, Changsha, Hunan, China

^c Faculty of Science and Technology, University of Macau, Taipa, Macau, Macao

^d Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China

^e The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China

Abstract

Catalytic microsweepers with a single-iron-atom center were designed to search for and inhibit Helicobacter pylori. Under dynamic navigation, the microsweepers displayed a large-range wall-adhering reciprocating motion, which increased the opportunity for interaction between microsweepers and H. pylori and further inhibited H. pylori through acid-responsive reactive oxygen species generation.

Chemical Communications

Single-atom-anchored microsweepers for H. pylori inhibition through dynamically navigated reciprocating locomotion†

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Single-atom-anchored microsweepers for H. pylori inhibition through dynamically navigated reciprocating locomotion

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