Issue 34, 2023
From the journal:

Chemical Communications

Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury†

Fang Yuan,a   Cuiling Zhang,*a   Xianzhu Luo,a   Xiaokun Shenb  and  Yuezhong Xian ORCID logo *a  

* Corresponding authors

a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China
E-mail: clzhang@chem.ecnu.edu.cn, yzxian@chem.ecnu.edu.cn

b Convalife (Shanghai) Co. Ltd., Shanghai 201203, China

Abstract

ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.

Graphical abstract: Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury

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Article information

DOI
https://doi.org/10.1039/D3CC00799E
Article type
Communication
Submitted
20 Feb 2023
Accepted
04 Apr 2023
First published
04 Apr 2023

Chem. Commun., 2023,59, 5122-5125

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Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury

F. Yuan, C. Zhang, X. Luo, X. Shen and Y. Xian, Chem. Commun., 2023, 59, 5122 DOI: 10.1039/D3CC00799E

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