Self-assembly of protein–DNA superstructures for alkaline phosphatase detection in blood

Yangyang Chang; Qian Zhang; Wei Xue; Yanfang Wu; Yi Liu; Meng Liu

doi:10.1039/D3CC00228D

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Self-assembly of protein–DNA superstructures for alkaline phosphatase detection in blood†

Yangyang Chang,‡^a Qian Zhang,‡^a Wei Xue,^a Yanfang Wu,

^b Yi Liu^c and Meng Liu

*^a

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* Corresponding authors

^a School of Environmental Science and Technology, Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian University of Technology, Dalian POCT Laboratory, Dalian, China
E-mail: mliu@dlut.edu.cn

^b School of Chemistry, The University of New South Wales, Sydney, NSW, Australia

^c Department of Neurology, Dalian Municipal Central Hospital Affiliated Hospital of Dalian Medical University, Dalian, China

Abstract

We designed a paper-based analytical device by integrating horseradish peroxidase (HRP)-encapsulated 3D DNA for visual detection of alkaline phosphatase (ALP). This device allows on-paper sample pre-treatment, target recognition and signal readout, enabling simple (without additional pre-treatment of blood samples) and rapid (within 23 min) determination of ALP in clinical samples.

This article is part of the themed collection: Chemical Communications HOT Articles 2023

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Article information

DOI: https://doi.org/10.1039/D3CC00228D
Article type: Communication
Submitted: 16 Jan 2023
Accepted: 21 Feb 2023
First published: 22 Feb 2023

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Chem. Commun., 2023,59, 3399-3402

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Self-assembly of protein–DNA superstructures for alkaline phosphatase detection in blood

Y. Chang, Q. Zhang, W. Xue, Y. Wu, Y. Liu and M. Liu, Chem. Commun., 2023, 59, 3399 DOI: 10.1039/D3CC00228D

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Chemical Communications

Self-assembly of protein–DNA superstructures for alkaline phosphatase detection in blood†

Abstract

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Self-assembly of protein–DNA superstructures for alkaline phosphatase detection in blood

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