Issue 25, 2023
From the journal:

Chemical Communications

Chemical control of phase separation in DNA solutions†

Samuel Hauf ORCID logo a  and  Yohei Yokobayashi ORCID logo *a  

* Corresponding authors

a Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan
E-mail: yohei.yokobayashi@oist.jp

Abstract

We designed a series of DNA sequences comprising a trinucleotide repeat segment and a small molecule-binding aptamer. Optimization of the DNA sequences and reaction conditions enabled chemical control of phase separation of DNA condensates. Our results demonstrate a new strategy to regulate biomolecular phase transition.

Graphical abstract: Chemical control of phase separation in DNA solutions

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Article information

DOI
https://doi.org/10.1039/D2CC06901F
Article type
Communication
Submitted
19 Dec 2022
Accepted
01 Mar 2023
First published
06 Mar 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 3751-3754

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Chemical control of phase separation in DNA solutions

S. Hauf and Y. Yokobayashi, Chem. Commun., 2023, 59, 3751 DOI: 10.1039/D2CC06901F

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