Issue 13, 2023

A “dual-key-and-lock” ratiometric fluorescent probe with biocompatibility and selectivity for imaging vicinal dithiol proteins

Abstract

TMR-TPE, a ratiometric fluorescent probe, was reported for the imaging of vicinal dithiol proteins (VDPs) in living cells. Profiting from the “dual-key-and-lock” design, TMR-TPE solves the toxicity problem of VDP probes (98% cell viability at 50 μM) and avoids the interference of small thiols (up to 10 mM GSH). The change of VDPs during drug-induced liver injury was monitored for the first time using TMR-TPE.

Graphical abstract: A “dual-key-and-lock” ratiometric fluorescent probe with biocompatibility and selectivity for imaging vicinal dithiol proteins

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2022
Accepted
17 Jan 2023
First published
18 Jan 2023

Chem. Commun., 2023,59, 1785-1788

A “dual-key-and-lock” ratiometric fluorescent probe with biocompatibility and selectivity for imaging vicinal dithiol proteins

G. Zou, Y. Wen, F. Bi, S. Chen, Y. Yu and J. Wang, Chem. Commun., 2023, 59, 1785 DOI: 10.1039/D2CC06422G

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