Issue 7, 2023
From the journal:

Chemical Communications

A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery†

Zhimei He, ORCID logo a   Wenjie Xiang,b   Qin Fan,b   Lianhui Wang ORCID logo b  and  Jie Chao ORCID logo *ab  

* Corresponding authors

a Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts & Telecommunications, Nanjing, P. R. China
E-mail: iamjchao@njupt.edu.cn

b Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, P. R. China

Abstract

A rectangle DNA origami nanostructure equipped with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is constructed. Combining the high prodrug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem presents therapeutic selectivity for NQO1-overexpressing MCF-7 cells over healthy L02 cells, offering a potent strategy for precision cancer therapy.

Graphical abstract: A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery

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Article information

DOI
https://doi.org/10.1039/D2CC06367K
Article type
Communication
Submitted
24 Nov 2022
Accepted
21 Dec 2022
First published
21 Dec 2022

Chem. Commun., 2023,59, 912-915

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A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery

Z. He, W. Xiang, Q. Fan, L. Wang and J. Chao, Chem. Commun., 2023, 59, 912 DOI: 10.1039/D2CC06367K

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