Issue 16, 2023

Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser

Abstract

In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G-quadruplex stabilisation. Hypoxic MCF7 cells incubated with the stabiliser displayed significant downregulation of oncogenes c-myc, bcl-2, and hif-1α. This study presents the first hypoxia-activatable G-quadruplex stabilization and transcriptional regulation.

Graphical abstract: Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2022
Accepted
16 Jan 2023
First published
17 Jan 2023

Chem. Commun., 2023,59, 2247-2250

Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser

B. Uyar, N. G. Ozsamur, F. S. Celik, I. Ozbayram and S. Erbas-Cakmak, Chem. Commun., 2023, 59, 2247 DOI: 10.1039/D2CC06347F

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