Issue 25, 2023

Photo/Ni dual-catalyzed radical defluorinative sulfonylation to synthesize gem-difluoro allylsulfones

Abstract

Radical defluorinative functionalization of α-trifluoromethyl styrenes represents an effective way toward gem-difluoroalkenes. There are general interests in developing novel synthetic protocols for defluorinative functionalization with various types of radicals. However, reports on the preparation of gem-difluoro allylsulfones via an S-centered radical pathway are limited. Herein, we developed a photo/nickel dual-catalyzed defluorinative sulfonylation that rapidly and reliably synthesizes gem-difluoro allylsulfones. The merit of this protocol is exhibited by its mild conditions and wide scope, thus providing a novel strategy for the sulfonyl radical participating in radical defluorinative coupling.

Graphical abstract: Photo/Ni dual-catalyzed radical defluorinative sulfonylation to synthesize gem-difluoro allylsulfones

Supplementary files

Article information

Article type
Communication
Submitted
02 Nov 2022
Accepted
27 Feb 2023
First published
02 Mar 2023

Chem. Commun., 2023,59, 3707-3710

Photo/Ni dual-catalyzed radical defluorinative sulfonylation to synthesize gem-difluoro allylsulfones

Y. Xu, S. Wang, Z. Liu, M. Guo and A. Lei, Chem. Commun., 2023, 59, 3707 DOI: 10.1039/D2CC05934G

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