Issue 9, 2023

A two-photon responsive hydroxyphenylquinazolinone (HPQ)-based fluorescent organic nanoprodrug for H2S release against oxidative stress

Abstract

Light-activated H2S donors have attracted considerable interest in understanding the physiological role and clinical potential of H2S, as their release is highly localized and controlled. Herein, we have evolved a new HPQ chromophore-based fluorescent organic nanosystem localized in a target area that tolerates oxidative stress and precisely releases H2S under one- and two-photon irradiation with real-time monitoring capability. The two-photon absorption cross-section of this new phototrigger was calculated to be 283 GM at 720 nm. H2S photorelease was also demonstrated in vitro on the MDA-MB-468 cell line in the presence of excess ROS. Our developed H2S nanoprodrug can be applied to living systems to release the H2S-gasotransmitter under laser irradiation in a phototherapeutic window.

Graphical abstract: A two-photon responsive hydroxyphenylquinazolinone (HPQ)-based fluorescent organic nanoprodrug for H2S release against oxidative stress

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2022
Accepted
29 Dec 2022
First published
29 Dec 2022

Chem. Commun., 2023,59, 1177-1180

A two-photon responsive hydroxyphenylquinazolinone (HPQ)-based fluorescent organic nanoprodrug for H2S release against oxidative stress

A. Chaudhuri, T. Singha, B. C. Jena, M. Shee, P. K. Datta, M. Mandal and N. D. P. Singh, Chem. Commun., 2023, 59, 1177 DOI: 10.1039/D2CC05768A

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