Drug self-framework delivery system-coated gold nanorods for multi-modal imaging and combination therapy for breast cancer

Shenglei Hou; Yuan Zhang; Meng Lian; Xin Xie; Qinghua Lu; Qiqing Zhang

doi:10.1039/D2CC05341A

Drug self-framework delivery system-coated gold nanorods for multi-modal imaging and combination therapy for breast cancer†

Shenglei Hou,^a Yuan Zhang,^b Meng Lian,^c Xin Xie,^d Qinghua Lu*^e and Qiqing Zhang

*^abf

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* Corresponding authors

^a Institute of Biomedical Engineering, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China; Post-doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou, P. R. China
E-mail: zhangqiq@126.com

^b Fujian Bote Biotechnology Co. Ltd, Fuzhou, Fujian, P. R. China

^c Shandong Engineering Laboratory for Clean Utilization of Chemical Resources, Weifang University of Science and Technology, Weifang, China

^d The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, China

^e School of Chemical Science and Engineering, Tongji University, Shanghai, P. R. China
E-mail: 16115@tongji.edu.cn

^f Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P. R. China

Abstract

Herein, we report a multifunctional nanodrug (Au NRs@DSFDSs NPs) by coating a drug self-framework delivery system (DSFDS) on Au NRs with absorption at 1300 nm via simple condensation polymerization, with the purpose of developing an efficient theranostic nanoagent with multi-modal imaging ability, and synergistic chemo-photothermal therapy (CT-PTT) for the monitoring and suppression of tumor growth. Thus, this strategy provides a new idea for the design of a multifunctional platform for the accurate and effective image-guided treatment of tumors.

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DOI: https://doi.org/10.1039/D2CC05341A
Article type: Communication
Submitted: 08 Oct 2022
Accepted: 29 Nov 2022
First published: 19 Dec 2022

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Chem. Commun., 2023,59, 1809-1812

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Drug self-framework delivery system-coated gold nanorods for multi-modal imaging and combination therapy for breast cancer

S. Hou, Y. Zhang, M. Lian, X. Xie, Q. Lu and Q. Zhang, Chem. Commun., 2023, 59, 1809 DOI: 10.1039/D2CC05341A

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Chemical Communications

Drug self-framework delivery system-coated gold nanorods for multi-modal imaging and combination therapy for breast cancer†

Abstract

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Drug self-framework delivery system-coated gold nanorods for multi-modal imaging and combination therapy for breast cancer

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