Issue 12, 2023
From the journal:

RSC Chemical Biology

Small molecule modulators of immune pattern recognition receptors†

Taku Tsukidate, ORCID logo ‡a   Charles W. Hespen ORCID logo ‡a  and  Howard C. Hang*ab  

* Corresponding authors

a Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, USA

b Department of Immunology and Microbiology and Department of Chemistry, Scripps Research, La Jolla, California 92037, USA

Abstract

Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize exciting developments in discovery and characterization of small molecule PRR modulators, focusing on Toll-like receptors (TLRs), NOD-like receptors (NLRs) and the cGAS-STING pathway. We also highlight PRRs that are currently lacking small molecule modulators and opportunities for chemical biology and therapeutic discovery.

Graphical abstract: Small molecule modulators of immune pattern recognition receptors

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Article information

DOI
https://doi.org/10.1039/D3CB00096F
Article type
Review Article
Submitted
21 Jun 2023
Accepted
03 Oct 2023
First published
23 Oct 2023
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2023,4, 1014-1036

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Small molecule modulators of immune pattern recognition receptors

T. Tsukidate, C. W. Hespen and H. C. Hang, RSC Chem. Biol., 2023, 4, 1014 DOI: 10.1039/D3CB00096F

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