Issue 9, 2023

Discovery of cisplatin-binding proteins by competitive cysteinome profiling

Abstract

Cisplatin is a widely used cancer metallodrug that induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was identified and functionally validated to contribute to cisplatin's cytotoxicity.

Graphical abstract: Discovery of cisplatin-binding proteins by competitive cysteinome profiling

Supplementary files

Article information

Article type
Communication
Submitted
28 Mar 2023
Accepted
22 Jul 2023
First published
01 Aug 2023
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2023,4, 670-674

Discovery of cisplatin-binding proteins by competitive cysteinome profiling

X. Wang, Y. Zhang and C. Wang, RSC Chem. Biol., 2023, 4, 670 DOI: 10.1039/D3CB00042G

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