Issue 20, 2023

Multivalency-enhanced enzyme inhibitors with biomolecule-responsive activity

Abstract

This work reports a polymeric adenosine triphosphate (ATP)-responsive trypsin inhibitor. The polymeric inhibitor was rationally obtained by optimizing the benzamidine and phenylboronic acid monomers, which could synergistically bind with the phosphate and ribose groups in ATP. The ATP-responsive trypsin activity shows its potential as a therapeutic drug for cancer-targeting cell inhibition.

Graphical abstract: Multivalency-enhanced enzyme inhibitors with biomolecule-responsive activity

Supplementary files

Article information

Article type
Communication
Submitted
06 Jul 2023
Accepted
27 Aug 2023
First published
01 Sep 2023

Biomater. Sci., 2023,11, 6770-6774

Multivalency-enhanced enzyme inhibitors with biomolecule-responsive activity

F. Ding, X. Li, X. Chen, Y. Ma and G. Pan, Biomater. Sci., 2023, 11, 6770 DOI: 10.1039/D3BM01132A

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