Issue 22, 2023

A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear architecture

Abstract

We report the relationships between linear vs. network polymer architecture and biomechanical outcomes including lubrication and cushioning when the polymers are applied to the surface of articulating knee cartilage. Aqueous formulations of the bioinspired polymer poly(2-methacryloyloxylethyl phosphorylcholine) (pMPC) exhibit tuneable rheological properties, with network pMPC exhibiting increased elasticity and viscosity compared to linear pMPC. Application of a polymer network, compared to a linear one, to articulating tissue surfaces reduces friction, lessens tissue strain, minimizes wear, and protects tissue – thereby improving overall tissue performance. Administration of the network pMPC to the middle carpal joint of skeletally mature horses elicits a safe response similar to saline as monitored over a 70 day period.

Graphical abstract: A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear architecture

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2023
Accepted
22 Sep 2023
First published
12 Oct 2023

Biomater. Sci., 2023,11, 7339-7345

A polymer network architecture provides superior cushioning and lubrication of soft tissue compared to a linear architecture

B. G. Cooper, C. D. DeMoya, K. J. Sikes, D. D. Frisbie, N. Phillips, B. B. Nelson, C. W. McIlwraith, C. E. Kawcak, L. R. Goodrich, B. D. Snyder and M. W. Grinstaff, Biomater. Sci., 2023, 11, 7339 DOI: 10.1039/D3BM00753G

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