Issue 8, 2023

Multivalent sialic acid materials for biomedical applications

Abstract

Sialic acid is a kind of monosaccharide expressed on the non-reducing end of glycoproteins or glycolipids. It acts as a signal molecule combining with its natural receptors such as selectins and siglecs (sialic acid-binding immunoglobulin-like lectins) in intercellular interactions like immunological surveillance and leukocyte infiltration. The last few decades have witnessed the exploration of the roles that sialic acid plays in different physiological and pathological processes and the use of sialic acid-modified materials as therapeutics for related diseases like immune dysregulation and virus infection. In this review, we will briefly introduce the biomedical function of sialic acids in organisms and the utilization of multivalent sialic acid materials for targeted drug delivery as well as therapeutic applications including anti-inflammation and anti-virus.

Graphical abstract: Multivalent sialic acid materials for biomedical applications

Article information

Article type
Review Article
Submitted
01 Oct 2022
Accepted
29 Nov 2022
First published
01 Dec 2022

Biomater. Sci., 2023,11, 2620-2638

Multivalent sialic acid materials for biomedical applications

Y. Cao, W. Song and X. Chen, Biomater. Sci., 2023, 11, 2620 DOI: 10.1039/D2BM01595A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements