Issue 2, 2023

Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection

Abstract

The barrier function of host cells enables intracellular bacteria to evade the lethality of the host immune system and antibiotics, thereby causing chronic and recurrent infections that seriously threaten human health. Currently, the main clinical strategy for the treatment of intracellular bacterial infections involves the use of long-term and high-dose antibiotics. However, insufficient intracellular delivery of antibiotics along with various resistance mechanisms not only weakens the efficacy of current therapies but also causes serious adverse drug reactions, further increasing the disease and economic burden. Improving the delivery efficiency, intracellular accumulation, and action time of antibiotics remains the most economical and effective way to treat intracellular bacterial infections. The rapid development of nanotechnology provides a strategy to efficiently deliver antibiotics against intracellular bacterial infections into cells. In this review, we summarize the types of common intracellular pathogens, the difficulties faced by antibiotics in the treatment of intracellular bacterial infections, and the research progress of several types of representative nanocarriers for the delivery of antibiotics against intracellular bacterial infections that have emerged in recent years. This review is expected to provide a reference for further elucidating the intracellular transport mechanism of nanocarrier-drug complexes, designing safer and more effective nanocarriers and establishing new strategies against intracellular bacterial infection.

Graphical abstract: Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection

Article information

Article type
Review Article
Submitted
14 Sep 2022
Accepted
06 Dec 2022
First published
06 Dec 2022
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2023,11, 432-444

Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection

C. Wang, Y. Yang, Y. Cao, K. Liu, H. Shi, X. Guo, W. Liu, R. Hao, H. Song and R. Zhao, Biomater. Sci., 2023, 11, 432 DOI: 10.1039/D2BM01489K

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