Issue 23, 2023

A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

Abstract

Peroxynitrite (ONOO), a highly reactive species, plays a key role in various physiological and pathological processes. Herein, a red-emitting fluorescent reporter perylenemonoimide–boronate ester (PMI-BE) was synthesized and utilized for ultrasensitive detection of ONOO. The unique feature of PMI-BE is its nanomolar sensitivity with high selectivity towards ONOO. Moreover, PMI-BE also detects endogenously generated ONOO in live cells.

Graphical abstract: A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

Supplementary files

Article information

Article type
Communication
Submitted
26 Aug 2023
Accepted
18 Oct 2023
First published
18 Oct 2023

Analyst, 2023,148, 5851-5855

A perylenemonoimide-based fluorescent probe: ultrasensitive and selective tracing of endogenous peroxynitrite in living cells

A. Khan, V. K. Meena, A. Silswal and A. L. Koner, Analyst, 2023, 148, 5851 DOI: 10.1039/D3AN01469J

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