Issue 47, 2022

Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy

Abstract

Simple biomolecule-based supramolecular nanomedicines hold great promise in cancer therapy, but their clinical translation is greatly hindered by low tumor-specificity and unsatisfactory antitumor performance. Herein, we developed an amino acid basedsupramolecular nanomedicine that could be co-activated by multiple stimuli in tumor tissue to trigger cascade catalytic reactions in situ for synergetic therapy. The supramolecular nanomedicine was developed based on a combination of coordination and hydrophobic noncovalent interactions among amphiphilic amino acids, glucose oxidase (GOx), copper ions, as well as doxorubicin (DOX)–camptothecin (CPT) prodrugs. The cascade reactions including the catalytic oxidation of glucose to generate H2O2, GSH reducing Cu2+ to Cu+, a Fenton-like reaction between H2O2 and Cu+ to produce hydroxyl radicals (˙OH), and ˙OH-triggered rapid release of dual parent drugs were specifically activated in tumor cells. With these cascade reactions, the catalytic-chemo synergetic therapy was realized for high-efficiency tumor suppression.

Graphical abstract: Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
26 Oct 2022
Accepted
14 Nov 2022
First published
24 Nov 2022

J. Mater. Chem. B, 2022,10, 9838-9847

Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy

E. Song, Q. Wu, R. Gao, X. Lan, Y. Zhang, H. Geng, C. Liu, F. Xu, Y. Li and C. Liu, J. Mater. Chem. B, 2022, 10, 9838 DOI: 10.1039/D2TB02326A

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