Issue 36, 2022

Epicatechin-assembled nanoparticles against renal ischemia/reperfusion injury

Abstract

Bioinspired and biosafety antioxidant nanoparticle assemblies from natural occurring molecules have been regarded as a class of effective therapeutic nanomaterials for addressing current inflammatory diseases such as acute kidney injury. In this study, a series of epicatechin-assembled nanoparticles have been developed via one-pot enzymatic polymerization of epicatechin. The prepared poly (epicatechin) (PEC) nanoparticles (NPs) showed excellent antioxidant capacity to scavenge multiple toxic free radicals, thus being able to effectively protect cells under oxidative stress conditions in vitro. Furthermore, in the renal ischemia/reperfusion model, blood renal function testing and renal tissue staining revealed a prominent therapeutic effect of PEC NPs. All these findings suggested that this class of bioinspired antioxidant nanoparticles provided a new therapeutic strategy for human ischemia/reperfusion-related diseases.

Graphical abstract: Epicatechin-assembled nanoparticles against renal ischemia/reperfusion injury

Supplementary files

Article information

Article type
Paper
Submitted
21 Jun 2022
Accepted
08 Aug 2022
First published
10 Aug 2022

J. Mater. Chem. B, 2022,10, 6965-6973

Epicatechin-assembled nanoparticles against renal ischemia/reperfusion injury

J. Zhang, H. Xie, T. Wang, H. Zhang, Z. Yang, P. Yang, Y. Li, X. Ma and Z. Gu, J. Mater. Chem. B, 2022, 10, 6965 DOI: 10.1039/D2TB01301K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements