Issue 37, 2022

Nanoscale patterning of polymers on DNA origami


The combination of DNA–origami and synthetic polymers paves the way to a new class of structurally precise biohybrid nanomaterials for diverse applications. Herein, we introduce the grafting to method with high conversions (70–90%) under ambient conditions to generate DNA–polymer conjugates, which can hybridized precisely to DNA–origami architectures. We generated homo and block copolymers from three different polymer families (acrylates, methacrylates and acrylamides), coupled them to single stranded DNA (ssDNA) and pattern different DNA–origami architectures to demonstrate the formation of precise surface nanopatterns.

Graphical abstract: Nanoscale patterning of polymers on DNA origami

Supplementary files

Article information

Article type
13 Apr 2022
04 Jun 2022
First published
08 Jun 2022
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2022,10, 7512-7517

Nanoscale patterning of polymers on DNA origami

N. Alleva, P. Winterwerber, C. J. Whitfield, D. Y. W. Ng and T. Weil, J. Mater. Chem. B, 2022, 10, 7512 DOI: 10.1039/D2TB00812B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity