Issue 20, 2022

Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles

Abstract

New materials chemistries are urgently needed to overcome the limitations of existing biomedical materials in terms of preparation, functionality and versatility, and also in regards to their compatibility with biological environments. Here, we show that Passerini reactions are especially suited for the preparation of drug delivery materials, as with relatively few steps, polymers can be synthesized with functionality installed enabling drug conjugation and encapsulation, self-assembly into micellar or vesicular architectures, and with facile attachment triggerable chemistries. The polymers can be made with a variety of building blocks and assemble into nanoparticles, which are rapidly internalized in triple negative breast cancer (TNBC) cells. In addition, the polymers transport drug molecules efficiently through 3D cell cultures, and when designed with chemistries allowing pH-mediated release, exhibit greater efficacy against TNBC cells compared to the parent drug.

Graphical abstract: Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
07 Jan 2022
Accepted
16 Apr 2022
First published
19 Apr 2022
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2022,10, 3895-3905

Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles

A. Travanut, P. F. Monteiro, S. Smith, S. M. Howdle, A. M. Grabowska, B. Kellam, M. A. R. Meier and C. Alexander, J. Mater. Chem. B, 2022, 10, 3895 DOI: 10.1039/D2TB00045H

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