Issue 12, 2022

Anisotropic plasmonic Pd-tipped Au nanorods for near-infrared light-activated photoacoustic imaging guided photothermal–photodynamic cancer therapy

Abstract

The integration of photothermal therapy (PTT) and photodynamic therapy (PDT) has become a promising cancer treatment method. Herein, anisotropic metal hetero-nanostructure Pd-tipped Au nanorods (PTA NRs) were fabricated, which exhibit plasmon-enhanced photothermal performance under near-infrared laser irradiation. Due to their anisotropic nanostructure, PTA NRs promote the generation of energetic hot electrons and prolong the separation time of electrons and holes. The hot electrons could generate heat energy through the electron–phonon relaxation process and produce reactive oxygen species through energy and electron transformation processes. Because of their high NIR absorption cross-section, as well as good photostability, PTA NRs can be used for NIR-activated photoacoustic imaging-guided PTT-PDT combination cancer therapy. Experiments in tumor-bearing mice proved that PTA NRs exhibit excellent anti-tumor effects, with little side effects on normal organs, making them promising for NIR cancer phototherapy.

Graphical abstract: Anisotropic plasmonic Pd-tipped Au nanorods for near-infrared light-activated photoacoustic imaging guided photothermal–photodynamic cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
01 Jan 2022
Accepted
18 Feb 2022
First published
22 Feb 2022

J. Mater. Chem. B, 2022,10, 2028-2037

Anisotropic plasmonic Pd-tipped Au nanorods for near-infrared light-activated photoacoustic imaging guided photothermal–photodynamic cancer therapy

C. Yang, W. Jiang, Y. Yu, H. Zhang, C. Cai and Q. Shen, J. Mater. Chem. B, 2022, 10, 2028 DOI: 10.1039/D2TB00002D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements