Lateral electric field inhibits gel-to-fluid transition in lipid bilayers

Abstract

We report evidence of lateral electric field-induced changes in the phase transition temperatures of lipid bilayers. Our atomic scale molecular dynamics simulations show that lateral electric field increases the melting temperature of DPPC, POPC and POPE bilayers. Remarkably, this shift in melting temperature is only induced by lateral electric field, and not normal electric field. This mechanism could provide new mechanistic insights into lipid-lipid and lipid-protein interactions in the presence of endogenous and exogenous electric fields.

Supplementary files

Article information

Article type
Paper
Submitted
04 Jun 2022
Accepted
01 Aug 2022
First published
05 Aug 2022

Soft Matter, 2022, Accepted Manuscript

Lateral electric field inhibits gel-to-fluid transition in lipid bilayers

N. Thomas and A. Agrawal, Soft Matter, 2022, Accepted Manuscript , DOI: 10.1039/D2SM00740A

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