Issue 33, 2022

Bioimaging agents based on redox-active transition metal complexes

Abstract

Detecting the fluctuation and distribution of various bioactive species in biological systems is of great importance in determining diseases at their early stages. Metal complex-based probes have attracted considerable attention in bioimaging applications owing to their unique advantages, such as high luminescence, good photostability, large Stokes shifts, low toxicity, and good biocompatibility. In this review, we summarized the development of redox-active transition metal complex-based probes in recent five years with the metal ions of iron, manganese, and copper, which play essential roles in life and can avoid the introduction of exogenous metals into biological systems. The designing principles that afford these complexes with optical or magnetic resonance (MR) imaging properties are elucidated. The applications of the complexes for bioimaging applications of different bioactive species are demonstrated. The current challenges and potential future directions of these probes for applications in biological systems are also discussed.

Graphical abstract: Bioimaging agents based on redox-active transition metal complexes

Article information

Article type
Review Article
Submitted
09 May 2022
Accepted
27 Jul 2022
First published
27 Jul 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 9468-9484

Bioimaging agents based on redox-active transition metal complexes

S. Xue, Y. Pan, W. Pan, S. Liu, N. Li and B. Tang, Chem. Sci., 2022, 13, 9468 DOI: 10.1039/D2SC02587F

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