Issue 20, 2022

A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

Abstract

The exploration of cellular organelle-specific anchoring photosensitizers with both prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) production capability is highly in demand but remains a severe challenge for effective cancer theranostics involving photodynamic therapy (PDT). In this contribution, we developed a cell membrane-targeting and NIR-emission photosensitizer having an aggregation-induced emission (AIE) tendency. The AIE photosensitizer, namely TBMPEI, is capable of lighting up and ablating cancer cells by means of a necroptosis procedure enabling cell membrane rupture and DNA degradation upon light irradiation, endowing TBMPEI with impressive performance for both in vitro and in vivo fluorescence imaging-guided PDT.

Graphical abstract: A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

Supplementary files

Article information

Article type
Edge Article
Submitted
03 Mar 2022
Accepted
12 Apr 2022
First published
19 Apr 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 5929-5937

A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

N. Niu, Y. Yu, Z. Zhang, M. Kang, L. Wang, Z. Zhao, D. Wang and B. Z. Tang, Chem. Sci., 2022, 13, 5929 DOI: 10.1039/D2SC01260J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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