Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona

Abstract

Solid porous and crystalline covalent organic frameworks (COFs) are characterized by their higher specific BET surface areas and functional pore walls, which allow the adsorption of various bioactive molecules inside the porous lattices. We have introduced a perylene-based COF, PER@PDA-COF-1, which acts as an effective porous volumetric reservoir for an anticancer drug, mitoxantrone (MXT). The drug-loaded COF (MXT–PER@PDA-COF-1) exhibited zero cellular release of MXT towards cancer cells, which can be attributed to the strong intercalation between the anthracene-dione motif of the drug and the perylene-based COF backbone. Here, we have introduced a strategy involving the serum-albumin-triggered intracellular release of mitoxantrone from MXT–PER@PDA-COF-1. The serum albumin acts as an exfoliating agent and as a colloidal stabilizer in PBS medium (pH = 7.4), rapidly forming a protein corona around the exfoliated COF crystallites and inducing the sustained release of MXT from the COF into tumorigenic cells.

Graphical abstract: Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona

Supplementary files

Article information

Article type
Edge Article
Submitted
15 Jan 2022
Accepted
02 Jun 2022
First published
18 Jun 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022, Advance Article

Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona

S. Bhunia, P. Saha, P. Moitra, M. A. Addicoat and S. Bhattacharya, Chem. Sci., 2022, Advance Article , DOI: 10.1039/D2SC00260D

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