Issue 9, 2022

Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines


This report describes a manganese-catalyzed radical [3 + 2] cyclization of cyclopropanols and oxime ethers, leading to valuable multi-functional 1-pyrrolines. In this redox-neutral process, the oxime ethers function as internal oxidants and H-donors. The reaction involves sequential rupture of C–C, C–H and N–O bonds and proceeds under mild conditions. This intermolecular protocol provides an efficient approach for the synthesis of structurally diverse 1-pyrrolines.

Graphical abstract: Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines

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Article information

Article type
Edge Article
03 Jan 2022
09 Feb 2022
First published
09 Feb 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 2669-2673

Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines

T. Feng, C. Liu, Z. Wu, X. Wu and C. Zhu, Chem. Sci., 2022, 13, 2669 DOI: 10.1039/D2SC00015F

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