Issue 44, 2022

Colorimetric and fluorescent detection of synthetic cathinones in oral fluid with meso-aryl BODIPYs and Cu(ii)

Abstract

Synthetic cathinones are a class of new psychoactive substances whose consumption has increased a lot and is widespread throughout the world. Thus, there is currently a need for rapid and simple detection of these drugs. In particular, detection of synthetic cathinones in oral fluid in drivers can be of great importance in preventing traffic accidents. Herein, we report two probes, based on BODIPY derivatives combined with Cu(II), which are able to detect these drugs both in water and in oral fluid, by changes in color and fluorescence. The determined limits of detection for ephedrone (as a model drug) are lower than the usual concentrations in saliva after intake of this type of drug. The sensing mechanism seems to be related to the cathinone induced reduction of Cu(II) to Cu(I) with concomitants changes in the BODIPY structure.

Graphical abstract: Colorimetric and fluorescent detection of synthetic cathinones in oral fluid with meso-aryl BODIPYs and Cu(ii)

Supplementary files

Article information

Article type
Paper
Submitted
18 Aug 2022
Accepted
03 Oct 2022
First published
20 Oct 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 28580-28585

Colorimetric and fluorescent detection of synthetic cathinones in oral fluid with meso-aryl BODIPYs and Cu(II)

J. Hernández-Contreras, M. Parra, S. Gil, A. M. Costero, P. Arroyo, F. Sancenón, R. Martínez-Máñez, J. A. Sáez and P. Gaviña, RSC Adv., 2022, 12, 28580 DOI: 10.1039/D2RA05188E

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