Issue 37, 2022

A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors

Abstract

Herein, we demonstrate a Pd catalyzed C-4 borylation of structurally complex chloroquinolines with bis(pinacolato)diboron under relatively simple and efficient conditions. Moreover, the borylated quinolines were converted into oxaborole, trifluoroborate salt and boronic acid and also rendered in the Suzuki reaction successfully. The method was also applied for the synthesis of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors. The strategy opens up new avenues for the functionalization of quinolines as potential probes and pharmacological agents for future biomedical research.

Graphical abstract: A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2022
Accepted
16 Aug 2022
First published
25 Aug 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 24187-24191

A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors

B. C. Das, P. Yadav, S. Das and J. C. He, RSC Adv., 2022, 12, 24187 DOI: 10.1039/D2RA05063C

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