Here we report the synthesis and genetic encoding of the lysine post translational modifications, β-hydroxybutyryl-lysine, isobutyryl-lysine and isovaleryl-lysine. The ability to obtain a homogenous protein samples with site-specific incorporation of these acylated lysine residues can serve as a powerful tool to study the biological role of lysine post translational modifications.
J. A. Christopher, S. A. Galbada Liyanage, E. M. Nicholson, W. D. Kinney and T. A. Cropp, RSC Adv., 2022, 12, 34142 DOI: 10.1039/D2RA04898A
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