Issue 41, 2022, Issue in Progress

Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine

Abstract

Nanoparticles capable of mimicking natural tissues represent a major technological advancement in regenerative medicine. In this pilot study, the development of a new nanohybrid composed of titanate nanoribbons to mimic the extracellular matrix is reported. During the first phase, nanoribbons were synthesized by hydrothermal treatment. Subsequently, titanate nanoribbons were functionalized by heterobifunctional polyethylene-glycol (PEG) to graft type I collagen on their surface. Biological properties of this new nanobiohybrid such as cytotoxicity to cardiac cells and platelet aggregation ability were evaluated. The so-formed nanobiohybrid permits cellular adhesion and proliferation favoring fine cardiac tissue healing and regeneration.

Graphical abstract: Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine

Supplementary files

Article information

Article type
Paper
Submitted
29 Jul 2022
Accepted
14 Sep 2022
First published
21 Sep 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 26875-26881

Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine

L. Maurizi, V. Bellat, M. Moreau, E. De Maistre, J. Boudon, L. Dumont, F. Denat, D. Vandroux and N. Millot, RSC Adv., 2022, 12, 26875 DOI: 10.1039/D2RA04753E

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