Issue 40, 2022, Issue in Progress

A new fluorescent boronic acid sensor based on carbazole for glucose sensing via aggregation-induced emission

Abstract

A water-soluble fluorescent sensor based on carbazole pyridinium boronic acid (CPBA) was designed and synthesized. Its structure has been confirmed by CHN and 1H and 13C NMR, FT-IR, and MS spectral data. Fluorescence studies of the synthesized chemosensor CPBA showed a selective ratiometric fluorescent response for glucose among different monosaccharides. The results specified that CPBA is a pH-sensitive sensor that behaves differently in the absence and presence of glucose in the pH range 4–10. The pH, DLS, Job's plot, UV-visible, and fluorescence titration studies showed that the selectivity of CPBA towards glucose is through the aggregation-induced emission (AIE) phenomenon. The fluorescence emission intensity of CPBA changes by more than 2100 fold by adding glucose, whereas it is 2 fold for fructose. The calculated binding constant value of CPBA for glucose (K = 2.3 × 106 M−1) is 85 times greater than for fructose, indicating the high affinity of the sensor for glucose.

Graphical abstract: A new fluorescent boronic acid sensor based on carbazole for glucose sensing via aggregation-induced emission

Supplementary files

Article information

Article type
Paper
Submitted
03 Jul 2022
Accepted
06 Sep 2022
First published
14 Sep 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 26201-26205

A new fluorescent boronic acid sensor based on carbazole for glucose sensing via aggregation-induced emission

M. Oloub, R. Hosseinzadeh, M. Tajbakhsh and M. Mohadjerani, RSC Adv., 2022, 12, 26201 DOI: 10.1039/D2RA04110C

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