Direct phosphorylation of benzylic C–H bonds under transition metal-free conditions forming sp3C–P bonds

Abstract

Direct phosphorylation of benzylic C–H bonds was achieved in a biphasic system under transition metal-free conditions. A selective radical/radical sp³C–H/P(O)–H cross coupling was proposed, and various substituted toluenes were applicable. The transformation provided a promising method for constructing sp³C–P bonds.