Trace-level detection of sulfonamide antibiotics using quaternary ammonium polymeric ionic liquid-based effervescence-enhanced dispersive solid-phase extraction followed by LC-DAD analysis in environmental waters

Abstract

Conventional ionic liquids possess several disadvantages, such as high viscosity, difficult sampling/retrieval, and great loss in aqueous solution, limiting their wide applications in the pretreatment field. To solve these drawbacks, we synthesized a quaternary ammonium polymeric ionic liquid (PIL) and pressed it into an effervescent tablet for developing an effervescence-enhanced dispersive solid-phase extraction method (QAP-EDSE). The pressed effervescent tablet was composed of PIL as an extractant, tartaric acid as an acidic source, NaHCO₃ as an alkaline source, and water-soluble starch as a filler, respectively. Under the CO₂-driven dispersion, the QAP-EDSE method integrated rapid enrichment, extraction, and dispersion into one synchronous step. Employing the one-factor-at-a-time approach, several important variables were optimized as follows: 200 mg of P[VBTHEA]Cl as sorbent, 400 μL of acetone as elution solvent, 5 min of elution, solution pH 9.0, and 1 : 1.25 molar ratio of alkaline to acidic sources. Combining LC-DAD analysis, this proposed approach offered the limits of detection as low as 0.11–0.31 μg L⁻¹ and satisfactory recoveries of 81.40–102.62% for five sulfonamides (SAs) in environmental waters. The lower relative standard deviations (1.9–6.7%) evidenced the higher intraday and interday experimental precision by this method. Overall, the newly developed method is environmentally benign, time-saving, and easy to operate with low detection limit and high recovery and thus shows excellent prospects in the trace-level detection of SAs in environmental waters.