Acellular bioactivity and drug delivery of new strontium doped bioactive glasses prepared through a hydrothermal process

Abstract

This work aims to study the kinetics of apatite layer formation on the surface of strontium doped binary bioactive glasses (BG: 63S37C) prepared for the first time by a hydrothermal process and evaluate their potential for drug loading and release using ibuprofen (IBU) as an anti-inflammatory drug vector. First, the binary glass 63S37C was doped with various amounts of strontium, from 0.2 to 1 mol%. Subsequently, the amorphous state of the samples and the microstructure were assessed by TGA, XRD, FTIR, ICP-AES, and SEM-EDS. Next, the in vitro bioactivity was evaluated by following the surface morphology and composition changes of soaked samples for up to 14 days at 37 °C in simulated bodily fluid (SBF). Finally, SEM-EDS spectroscopy showed clearly the appearance of needle-shaped apatite on amorphous glass substrates at the earlier stages of immersion for bioglasses doped with strontium. These findings are also confirmed with XRD and FTIR analysis. Furthermore, 63S37C BG proved that the drug release increased with increasing strontium content. Altogether, this novel class of bioactive glasses may be considered to have a promising future for biomedical applications.