Issue 29, 2022, Issue in Progress

Quantitative glycoproteomics of high-density lipoproteins

Abstract

In this work, we developed a targeted glycoproteomic method to monitor the site-specific glycoprofiles and quantities of the most abundant HDL-associated proteins using Orbitrap LC-MS for (glyco)peptide target discovery and QqQ LC-MS for quantitative analysis. We conducted a pilot study using the workflow to determine whether HDL protein glycoprofiles are altered in healthy human participants in response to dietary glycan supplementation.

Graphical abstract: Quantitative glycoproteomics of high-density lipoproteins

Supplementary files

Article information

Article type
Paper
Submitted
08 Apr 2022
Accepted
09 Jun 2022
First published
23 Jun 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 18450-18456

Quantitative glycoproteomics of high-density lipoproteins

X. Tang, M. Wong, J. Tena, C. Zhu, C. Rhodes, Q. Zhou, A. Vinjamuri, A. Oloumi, S. Boddu, G. Luxardi, E. Maverakis, C. B. Lebrilla and A. M. Zivkovic, RSC Adv., 2022, 12, 18450 DOI: 10.1039/D2RA02294J

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