Issue 21, 2022, Issue in Progress
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RSC Advances

A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction†

Hanglu Ying,ab   Jie Yao,ab   Fan Wu, ORCID logo *ab   Yufen Zhao ORCID logo ab  and  Feng Ni ORCID logo *ab  

* Corresponding authors

a Institute of Drug Discovery Technology, Ningbo University, Ningbo, Zhejiang, P. R. China
E-mail: wufan@nbu.edu.cn, nifeng@nbu.edu.cn

b Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang, P. R. China

Abstract

A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction of the aryloxy phosphoramidate prodrugs library for potential SAR studies.

Graphical abstract: A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction

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Article information

DOI
https://doi.org/10.1039/D2RA01995G
Article type
Paper
Submitted
28 Mar 2022
Accepted
19 Apr 2022
First published
29 Apr 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 13111-13115

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A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction

H. Ying, J. Yao, F. Wu, Y. Zhao and F. Ni, RSC Adv., 2022, 12, 13111 DOI: 10.1039/D2RA01995G

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