Issue 28, 2022
From the journal:

RSC Advances

Targeted drug release system based on pH-responsive PAA-POSS nanoparticles†

Won Jung Kim,a   Eu Hyun Lee,a   Yong-Jin Kwon,b   Sang-Kyu Ye*b  and  Kyu oh Kim ORCID logo *a  

* Corresponding authors

a Department of Fiber System Engineering, Dankook University, 152, Jookjeon-ro, Suji-gu, Yongin-si, Gyeonggi-do, Republic of Korea

b Department of Pharmacology, Seoul National University College of Medicine, Republic of Korea
E-mail: sangkyu@snu.ac.kr

Abstract

An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 ± 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line.

Graphical abstract: Targeted drug release system based on pH-responsive PAA-POSS nanoparticles

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Article information

DOI
https://doi.org/10.1039/D2RA01141G
Article type
Paper
Submitted
20 Feb 2022
Accepted
05 May 2022
First published
22 Jun 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 18209-18214

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Targeted drug release system based on pH-responsive PAA-POSS nanoparticles

W. J. Kim, E. H. Lee, Y. Kwon, S. Ye and K. O. Kim, RSC Adv., 2022, 12, 18209 DOI: 10.1039/D2RA01141G

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